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Image Search Results
Journal: JHEP Reports
Article Title: The future of clinical trials of gut microbiome therapeutics in cirrhosis
doi: 10.1016/j.jhepr.2024.101234
Figure Lengend Snippet: Indications for microbiome therapeutics in cirrhosis.
Article Snippet:
Techniques: Bacteria, Infection, Permeability
Journal: JHEP Reports
Article Title: The future of clinical trials of gut microbiome therapeutics in cirrhosis
doi: 10.1016/j.jhepr.2024.101234
Figure Lengend Snippet: Biological targets of microbiome therapeutics in cirrhosis. Microbiome therapeutics have multiple potential mechanisms in cirrhosis, including several which could improve intestinal barrier function including increasing SCFA, secondary bile acid, tight junction protein, and antimicrobial peptide production. SCFAs are a primary energy source for colonic enterocytes, which allow them to produce tight junctions and mucin, thus bolstering the epithelial barrier. Patients with cirrhosis also have elevated intestinal epithelial cell inflammation and a more permeable gut barrier. By changing microbiome composition and function, ammonia and endotoxin production and translocation could decrease. Adapted from published figure. SCFA, short-chain fatty acid.
Article Snippet:
Techniques: Translocation Assay
Journal: JHEP Reports
Article Title: The future of clinical trials of gut microbiome therapeutics in cirrhosis
doi: 10.1016/j.jhepr.2024.101234
Figure Lengend Snippet: Microbiome therapeutics in cirrhosis.
Article Snippet:
Techniques: Probiotics, Clinical Proteomics, Translocation Assay, Bacteria
Journal: Scientific Reports
Article Title: Evaluation of the upper airway microbiome and immune response with nasal epithelial lining fluid absorption and nasal washes
doi: 10.1038/s41598-020-77289-3
Figure Lengend Snippet: Common microbial ecology indices of the upper airway microbiome in children with paired samples based on 16S ribosomal RNA sequencing and according to sample type. ( A ) Grouped bar graphs of selected indices showing no differences in community richness between nasal filters and nasal washes at the amplicon sequence variant unit (ASV) level. ( B ) Box-and-whisker plots of selected indices showing no differences in community α-diversity between nasal filters than in nasal washes at the ASV level. ( C ) Principal coordinates analysis (PCoA) plot of Bray–Curtis dissimilarities showing no distinct clustering by sample type at the ASV level. The lines connect samples with their group centroids. ( A , B ) were generated with the R package ggplot2 version 3.0.0 ( https://cran.r-project.org/web/packages/ggplot2/index.html) ; ( C ) was generated in vegan version 2.5-2 ( https://cran.r-project.org/web/packages/vegan/index.html ) and minor aesthetic edits were performed with Inkscape version 1.0.
Article Snippet: First, eukaryotic DNA was depleted using the
Techniques: RNA Sequencing Assay, Amplification, Sequencing, Variant Assay, Whisker Assay, Generated
Journal: Scientific Reports
Article Title: Evaluation of the upper airway microbiome and immune response with nasal epithelial lining fluid absorption and nasal washes
doi: 10.1038/s41598-020-77289-3
Figure Lengend Snippet: Common microbial ecology indices of the upper airway microbiome in adults with paired samples based on 16S ribosomal RNA sequencing and according to sample type. ( A ) Grouped bar graphs of selected indices showing higher community richness in nasal filters than in nasal washes at the amplicon sequence variant (ASV) level. ( B ) Box-and-whisker plots of selected indices showing higher community α-diversity in nasal filters than in nasal washes at the ASV level. ( C ) Principal coordinates analysis (PCoA) plot of Bray–Curtis dissimilarities showing distinct clustering by sample type at the ASV level. The lines connect samples with their group centroids. ( A , B ) were generated with the R package ggplot2 version 3.0.0 ( https://cran.r-project.org/web/packages/ggplot2/index.html ) ; ( C ) was generated in vegan version 2.5–2 ( https://cran.r-project.org/web/packages/vegan/index.html ) and minor aesthetic edits were performed with Inkscape.
Article Snippet: First, eukaryotic DNA was depleted using the
Techniques: RNA Sequencing Assay, Amplification, Sequencing, Variant Assay, Whisker Assay, Generated